Timokinon metotreksatın neden olduğu kalp hasarını azaltır: sıçanlarda histopatolojik bir çalışma

Purpose: The study aimed to evaluate the effect of thymoquinone on cardiac tissue in MTX-induced toxicity rats with various parameters.
 Materials and Methods: Group I (n:8) was administered intraperitoneal saline for 10 days. Intraperitoneal olive oil applied II III a single dose 20 mg/kg Methotrexate (MTX) (500 mg/20 ml) intraperitoneally 1st day experiment. Since liquid form, no solvent used. IV received Thymoquinone (THQ) V (MTX: (20 day); THQ: 10mg/kg i.p. At end experimental period, were sacrificed analysis heart tissue. structure evaluated by haematoxylin-eosin staining. Immunohistochemically, connexin-43, HSP90, HIF-1α antibodies stained. results analysed statistically. 
 Results: According our results, has positive expression Cx43, one proteins providing transmission intercalary discs, chaperones cell, against MTX provides significant improvement showing cardioprotective histopathologically.
 Conclusion: THQ could be considered crucial phytochemical cardiotoxicity.